1.Nitrates (e.g., nitroglycerin, isosorbide dinitrate): Cialis and nitrates both lower blood pressure. Taking them together can cause a significant and potentially life-threatening drop in blood pressure (hypotension), leading to dizziness, fainting, or even heart attack or stroke. It is contraindicated to use Cialis with nitrates or recreational "poppers" (amyl nitrites).
2.Alpha-blockers (e.g., prazosin, terazosin, tamsulosin): Both Cialis and alpha-blockers relax blood vessels, which can lead to excessive blood pressure reduction when used together. This may result in dizziness, fainting, or orthostatic hypotension (a sudden drop in blood pressure when standing). If needed, your doctor may adjust the dosage or recommend spacing the medications.
3.Other antihypertensive drugs (e.g., atenolol, propranolol, enalapril, lisinopril): Cialis can enhance the blood-pressure-lowering effects of these medications. While this interaction is usually less severe than with nitrates or alpha-blockers, it can still cause dizziness or fainting in sensitive individuals. Close monitoring of blood pressure is recommended.
Cialis (tadalafil) can interact with certain foods and beverages, potentially altering its effectiveness or increasing the risk of side effects. Here are the key drug-food interactions to be aware of:
| Dosage | Quantity | Flag | Occipital Volume | Tadalafil PSA |
|---|---|---|---|---|
| 2mg | 1 tablet | 20 mL | 4,829 µ5 | 4,829 μ5 |
| Cialis (tadalafil) 2mg-4mg | 1.7 billion |
1. KD. Tripathi. Androgens and Drugs for Erectile Dysfunction. Essentials of medical pharmacology. Seventh edition. 2013. Page-304.
2. Adam M Henrie, James J Nawarskas, and Joe R Anderson. Clinical utility of tadalafil in the treatment of pulmonary arterial hypertension: an evidence-based review. NIH. National Library of Medicine. National Center for Biotechnology Information. PMC. PubMed Central. November 2015. [Accessed on November 08th, 2023]https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4636095/
3. Accord Healthcare Limited. Electronic Medicines Compendium (EMC). [Revised in October 2021] [Accessed on November 08th, 2023]https://www.medicines.org.uk/emc/files/pil.8637.pdf
4. Leeford Healthcare Private Ltd. Bigfun-36.https://www.leeford.in/product/556/bigfun-36
5. Central Drugs Standard Control Organization. Tadalafil tablet 20 mg (Additional Indication). [Revised in November 2009]. Tadalafil 10mg/20mg Tablets. [Revised in September 2003] [Accessed on November 08th, 2023]https://cdscoonline.gov.in/CDSCO/Drugs
Central drug surveillance system (CDS) - Asia/Pacific region.https://www.ncbi.nlm.nra.re/cdscoonline/CDSCO/Drugs/556/6. Eli Lilly. Darunavir post-patentimalachyosis vaccine.https://www.luc.com/Livesiro/PDFs/1381.pdf
Tablet. Anastrozole. US.https://www.pdr.usda.gov/About-Drugs/About-EMC/Product/556/Tablet-like substance. Europe.https://www.pdr.org.uk/About-EMC7.4.2. Parties of the estrogens and prostate-specific antigen (E2a) inhibitor/benign prostate hyperplasia (BPH) study.https://www.arrest.gov.uk/PRNewsw/ABSTRACT/ABSTRACT.pdf
7.4.3. Patients with basal cell anaplasia (PCA) with or without squamous cell carcinoma (SCC) and/or endometriosis.
Tadalafil belongs to the group of medicines called phosphodiesterase type 5 (PDE 5) inhibitors, primarily used to treat erectile dysfunction (impotence) and benign prostatic hyperplasia (BPH). Erectile dysfunction is the inability to keep a hard and erect penis suitable for sexual activity. Benign prostatic hyperplasia, also called prostate enlargement, is the non-cancerous growth of the prostate gland.
Tadalafil contains ‘Tadalafil’, which works by relaxing the blood vessels in the penis; this allows the blood to flow into the penis when the person is sexually excited. Thereby, it helps to treat erectile dysfunction. Tadalafil relaxes the bladder and prostate muscles, thereby reducing enlarged prostate symptoms such as difficulty in urination and urgent need to urinate.
You are advised to take Tadalafil for as long as your doctor has prescribed it for you, depending on your medical condition. In some cases, you may experience certain common side effects, such as headache, back pain, muscle pain, pain in the legs and arms, nasal congestion, indigestion, and facial flushing. Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side effects persistently.
Do not take Tadalafil if you are taking nitrates (used to treat angina), riociguat (used to treat pulmonary hypertension) or alpha-blockers; if you have heart problems or stroke, low blood pressure or uncontrolled high blood pressure. Tadalafil is not intended for use in women. Tadalafil may cause dizziness, so drive with caution. Avoid consuming alcohol as it might cause increased dizziness. Tadalafil should not be given to children as safety and effectiveness have not been established. Keep your doctor informed about your health condition and the medicines you are taking to avoid unpleasant side effects.
Read the leaflet provided with this medicine before taking this medicine and after use. Tadalafil: Are you taking any other medicines?You should not take Tadalafil if you are taking any of the following medicines without consulting your doctor:
allergies to Tadalafil or any other PDE5 inhibitor?alpha-blockers are used to treat depression, and may cause dizziness, so avoid using Tadalafil if you have ever had any side effects after taking any medicine. Dulcolium your doctor prescribed Tadalafil may cause increased dizziness, so avoid Tadalafil if you have any allergy to Tadalafil or any other PDE5 inhibitor.
Take Tadalafil exactly as your doctor has told you. Tadalafil is taken on an as-needed basis, usually 30 minutes before sexual activity. Your sexual activity may vary depending on your body size and other factors. Do not take this medicine if you are unable to get or keep an erection, Prinzmetal's disease is a condition where you lose or become seriously ill after taking Tadalafil. If you need to have sex more than once, talk to your doctor as he or she may want to change the dose or recommend that you take this medicine whenever you want.How to take this medicinePlease read the enclosed leaflet carefully to ensure you take it exactly as shown in the enclosed leaflet.
Take this medicine with a large glass of water as directed by your doctor or with a meal that contains fat. This medicine can be taken with or without food, but some foods may take longer to work if you take this medicine with a large glass of water. This can be because water has been meal-related for some time, so it takes time for the medicine to start working after you are dehydrated. Keep taking this medicine even if you feel well. • Do not take this medicine with a heavy meal, as it may lead to some of the medicine's effectiveness. Some medicines may take longer to start working after you are dehydrated; like Tadalafil, Amoxapine, Pimozide, Rivastigmine, Sildenafil, Tadalafil USP, Vardenafil, Zyban, etc. Please check with your doctor or pharmacist if you are not sure.Tell your doctor if you have any kidney or liver problems, and if you are taking nitrates, or other medicines that increase your blood pressure.Tadalafil belongs to the group of medicines called phosphodiesterase type 5 (PDE 5) inhibitors, primarily used to treat erectile dysfunction (impotence) and benign prostatic hyperplasia (BPH). Erectile dysfunction is the inability to keep a hard and erect penis suitable for sexual activity. Benign prostatic hyperplasia, also called prostate enlargement, is the non-cancerous growth of the prostate gland.
Tadalafil contains ‘Tadalafil’, which works by relaxing the blood vessels in the penis; this allows the blood to flow into the penis when the person is sexually excited. Thereby, it helps to treat erectile dysfunction. Tadalafil relaxes the bladder and prostate muscles, thereby reducing enlarged prostate symptoms such as difficulty in urination and urgent need to urinate.
You are advised to take Tadalafil for as long as your doctor has prescribed it for you, depending on your medical condition. In some cases, you may experience certain common side effects, such as headache, back pain, muscle pain, pain in the legs and arms, nasal congestion, indigestion, and facial flushing. Most of these side effects do not require medical attention and will resolve gradually over time. However, you are advised to talk to your doctor if you experience these side effects persistently.
Do not take Tadalafil if you are taking nitrates (used to treat angina), riociguat (used to treat pulmonary hypertension) or alpha-blockers; if you have heart problems or stroke, low blood pressure or uncontrolled high blood pressure. Tadalafil is not intended for use in women. Tadalafil may cause dizziness, so drive with caution. Avoid consuming alcohol as it might cause increased dizziness. Tadalafil should not be given to children as safety and effectiveness have not been established. Keep your doctor informed about your health condition and the medicines you are taking to avoid unpleasant side effects.
Read the carefully before taking Tadalafil for BPH ingerafil dosage for erectile dysfunctionThe most common side effects of Tadalafil include back pain, headache, indigestion, and nasal congestion. However, they are less frequent. They are used as a precaution for high blood pressure and other conditions. They are also used for the treatment of male pattern baldness to prevent further hair loss.
More severe side effects include severe vision problems, an eye condition called non-arteritic anterior ischemic optic neuropathy (NAION), more commonly known asgmentation of blood vessels in the lungs, and retinal vein occlusion (RVO), a rare cause of vision loss in rare cases. If any of these side effects persist or worsen, tell your doctor right away. You may need to adjust the dosage of Tadalafil or discontinue the medicine at any time. Tadalafil should not be taken with medications that can increase the risk of common side effects such as dizziness, nasal congestion, indigestion, and facial flushing.
Who should not take Tadalafil?Tadalafil is not recommended for people who are allergic to or have had a history of allergic reactions to tadalafil or any other ingredients in the medicine.
Tadalafil should not be taken if you are taking nitrates (used to treat angina) or alpha-blockers, or any other medications that can cause a dangerous drop in blood pressure, as this may lead to a heart attack or stroke. Tadalafil should not be taken with medicines that can cause a serious drop in blood pressure, as these may lead to a high blood pressure that will get worse within a few days of starting treatment.
Symptoms of an allergic reaction may include tightness of the face, arm or leg, pain or discomfort in the legs, ankle or foot, headache, dizziness, or nausea. If any of these apply to you, tell your doctor immediately.
Tadalafil should not be taken by patients who are taking riociguat or who are taking users of an alpha-blocker, as these may lead to a serious blood pressure drop.
Do not take tadalafil if you are taking or have recently taken any other medications, including prescription medicines such as riociguat or vardenafil. Some examples of medications that can increase your blood pressure include alpha-blockers, other medications that relax the bladder and prostate muscles and other treatments for erectile dysfunction, among others.
Drug-Drug Interactions:Tadalafil+dapoxetine may have interaction with anti-hypertensive (amlodipine, lisinopril, losartan, metoprolol, riociguat), alpha-blockers (tamsulosin), anti-anginal (nitroglycerin), anti-fungal (ketoconazole, itraconazole), antibiotics (erythromycin, clarithromycin), anti-TB (rifampicin), anticonvulsants (phenobarbital, phenytoin, carbamazepine), anti-HIV (ritonavir, saquinavir, nelfinavir), pain-killers (tramadol), anti-depressants (lithium, nefazodone), MAO inhibitor (Isocarboxazid, Phenelzine, Selegiline, and Tranylcypromine).
Drug-Food Interactions:Avoid consumption of alcohol as it may temporarily impair your ability to get an erection. Also, do not take St John's wort plant (a natural remedy to treat depression).
Drug-Disease Interactions:Tadalafil+dapoxetine may have interactions with cardiovascular/heart disease, renal dysfunction (kidney impairment), pulmonary disease, alcoholism, liver disease, seizure disorder, hearing loss, retinitis pigmentosa (loss of vision), and priapism (prolonged erection of the penis).
Judd M, Kaminowitz M: Cardiovascular/heart disease. New England J Med. 2019; 4:e80-e85.
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